1. Zhentong Zhu, Xiaozheng Duan, Qiao Li, Ruiping Wu, Yesheng Wang, Bingling Li*, Low-Noise Nanopore Enables In-Situ and Label-Free Tracking of Trigger-Induced DNA Molecular Machine at Single Molecular Level, Journal of American Chemical Society, 2020, 142, 9, 4481-4492.
2. Zhentong Zhu, Ruiping Wu, Bingling Li*, Exploration of solid-state nanopores in characterizing reaction mixtures generated from a catalytic DNA assembly circuit，Chemical Science, 2019,10, 1953-1961.
3. Yidan Tang, Baiyang Lu, Zhentong Zhu and Bingling Li*，Establishment of a universal and rational gene detection strategy through three-way junctionbased remote transduction，Chemical Science, 9 (2018) 760-769.
4. Zhentong Zhu, Ya Zhou, Xiaolong Xu, Ruiping Wu, Yongdong Jin*, and Bingling Li*，Adaption of a Solid-State Nanopore to Homogeneous DNA Organization Verification and Label-Free Molecular Analysis without Covalent Modification, Analytical Chemistry, 90（2018）814–820.
5. Yidan Tang, Huan Li, Bingling Li*, Homogeneous and universal transduction of various nucleic acids to an off-shelf device based on programmable toehold switch sensing, Chemical Communications, 2020,56, 2483-2486.
6. Yidan Tang, Zhentong Zhu, Baiyang Lu and Bingling Li*, Spatial organization based reciprocal switch of enzyme-free nucleic acid circuit, Chemical Communications, 52 (2016) 13043-13046.
7. Ruiping Wu, Zhentong Zhu, Xiaolong Xu, Chunmiao Yu, Bingling Li*, An investigation of solid-state nanopores on label-free metal-ion signalling via the transition of RNA-cleavage DNAzyme and the hybridization chain reaction, Nanoscale, 2019,11, 10339-10347.
8. 唐艺丹，刘一辰，吕佰阳，郭路路，发卡型万能传导在基于核酸分子线路的 基因诊断中的应用和性能优化，《分析化学》，2018， 46， 865-867。
1. 发明专利：一种基于血糖仪检测的检测载体
专利号：ZL201910133154.0.
发明(设计)人：李冰凌 唐艺丹
授权公告日：2020-09-21
2. 发明专利：一种双发夹连接介导恒温扩增的核酸检测新方法
专利号：202011073243.X
发明(设计)人：李冰凌 李欢 唐艺丹 吕佰阳
申请日：2020-10-09
3. 发明专利：基实于三通连接-核酸分子线路换能器的分子检测方法
专利号：201711171462.X.
发明(设计)人：吕佰阳 李冰凌 唐艺丹
申请日：2017-11-22
1.Bingling Li, Andrew D. Ellington, ''Electrochemical Techniques as Powerful Readout Methods for Aptamer-based Biosensors' (Chapter 9, 211-241) in: RSC-Biomolecular Sciences Series-DNA Conjugates and Sensors, Keith R. Fox and Tom Brown (Ed.), Royal Society of Chemistry, 2012.
2. Bingling Li, Hui Wei, Shaojun Dong, "STRATEGY FOR USE OF SMART ROUTES TO PREPARE LABEL-FREE APTASENSORS FOR BIOASSAY USING DIFFERENT TECHNIQUES" (Chapter 12, 251-290) in: Aptamers in Bioanalysis, M. Mascini (Ed.), Wiley-VCH, 2009.
1、核酸分子线路创新设计和分析应用
针对现有商品化核酸检测试剂假象误诊频发、精准度低、便携性或通用性差等方面的各项实用化缺陷，开发高性能“零背景-催化发卡结构自组装(CHA)”新体系，并提出具有通用指导意义的设计和应用法则; 进而发展出“恒温扩增-核酸分子线路”联用基因检测新原理、试剂及便携化装置，已实现多种重大疾病和传染性微生物的灵敏、精准和便携分析；其中针对新冠多个核酸位点开发出精准荧光检测试剂、可视化装置和试纸条；其中一项试剂已经转让企业。
2、基于固相纳米孔的核酸组装表征新方法
针对核酸分子线路和组装表征方法少、表征信息不全面和准确性差等影响其深入理解和性能优化的科学技术难题，首次提出基于高介电常数分子的固相纳米孔降噪机理，显著提升固相纳米孔对核酸组装体和小尺寸待测物的时空分辨率，进而建立了固相纳米孔单分子技术对核酸分子线路和组装的精细化表征新方法，有助于推动单分子信息学在精细化表征、动态分析、基因分型、信息存储和非水相体系等方面的创新应用。
人才队伍
